The SWI/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers

Genes encoding subunits of SWI/SNF (BAF) chromatin remodelling complexes are collectively altered in over 20% of human malignancies, but the mechanisms by which these complexes alter chromatin to modulate transcription and cell fate are poorly understood. Utilizing mouse embryonic fibroblast and can...

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Udgivet i:Nat Commun
Main Authors: Alver, Burak H., Kim, Kimberly H., Lu, Ping, Wang, Xiaofeng, Manchester, Haley E., Wang, Weishan, Haswell, Jeffrey R., Park, Peter J., Roberts, Charles W. M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5343482/
https://ncbi.nlm.nih.gov/pubmed/28262751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14648
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