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A novel class of apical sodium--dependent bile salt transporter inhibitors: 1-(2,4-bifluorophenyl)-7-dialkylamino-1,8-naphthyridine-3-carboxamides

The apical sodium--dependent bile acid transporter (ASBT) is the main transporter to promote re-absorption of bile acids from the intestinal tract into the enterohepatic circulation. Inhibition of ASBT could increase the excretion of bile acids, thus increasing bile acid synthesis and consequently c...

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Pubblicato in:Acta Pharm Sin B
Autori principali: Liu, Hongtao, Pang, Guoxun, Ren, Jinfeng, Zhao, Yue, Wang, Juxian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5343113/
https://ncbi.nlm.nih.gov/pubmed/28303230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2016.11.005
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