(1)H, (15)N, (13)C backbone resonance assignments of human soluble catechol O-methyltransferase in complex with S-adenosyl-l-methionine and 3,5-dinitrocatechol

Catechol O-methyltransferase (COMT) is an enzyme that plays a major role in catechol neurotransmitter deactivation. Inhibition of COMT can increase neurotransmitter levels, which provides a means of treatment for Parkinson’s disease, schizophrenia and depression. COMT exists as two isozymes: a solub...

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Vydáno v:Biomol NMR Assign
Hlavní autoři: Czarnota, Sylwia, Baxter, Nicola J., Cliff, Matthew J., Waltho, Jonathan P., Scrutton, Nigel S., Hay, Sam
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Netherlands 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5343089/
https://ncbi.nlm.nih.gov/pubmed/27981425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12104-016-9720-9
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