Antidyskinetic Effects of MEK Inhibitor Are Associated with Multiple Neurochemical Alterations in the Striatum of Hemiparkinsonian Rats

L-DOPA-induced dyskinesia (LID) represents one of the major problems of the long-term therapy of patients with Parkinson's disease (PD). Although, the pathophysiologic mechanisms underlying LID are not completely understood, activation of the extracellular signal regulated kinase (ERK) is recog...

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Vydáno v:Front Neurosci
Hlavní autoři: Chen, Guiqin, Nie, Shuke, Han, Chao, Ma, Kai, Xu, Yan, Zhang, Zhentao, Papa, Stella M., Cao, Xuebing
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2017
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5343040/
https://ncbi.nlm.nih.gov/pubmed/28337120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2017.00112
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