Exosomal biomarkers of brain insulin resistance associated with regional atrophy in Alzheimer's disease

Brain insulin resistance (IR), which depends on insulin‐receptor‐substrate‐1 (IRS‐1) phosphorylation, is characteristic of Alzheimer's disease (AD). Previously, we demonstrated higher pSer312‐IRS‐1 (ineffective insulin signaling) and lower p‐panTyr‐IRS‐1 (effective insulin signaling) in neural...

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Bibliografiske detaljer
Udgivet i:Hum Brain Mapp
Main Authors: Mullins, Roger J., Mustapic, Maja, Goetzl, Edward J., Kapogiannis, Dimitrios
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342917/
https://ncbi.nlm.nih.gov/pubmed/28105773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hbm.23494
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