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Exosomal biomarkers of brain insulin resistance associated with regional atrophy in Alzheimer's disease
Brain insulin resistance (IR), which depends on insulin‐receptor‐substrate‐1 (IRS‐1) phosphorylation, is characteristic of Alzheimer's disease (AD). Previously, we demonstrated higher pSer312‐IRS‐1 (ineffective insulin signaling) and lower p‐panTyr‐IRS‐1 (effective insulin signaling) in neural...
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| Publicado no: | Hum Brain Mapp |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5342917/ https://ncbi.nlm.nih.gov/pubmed/28105773 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hbm.23494 |
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