Heme oxygenase-1 (HO-1)/carbon monoxide (CO) axis suppresses RANKL-induced osteoclastic differentiation by inhibiting redox-sensitive NF-κB activation

Heme oxygenase (HO-1) catalyzes heme to carbon monoxide (CO), biliverdin/bilirubin, and iron and is known to prevent the pathogenesis of several human diseases. We assessed the beneficial effect of heme degradation products on osteoclastogenesis induced by receptor activator of NF-κB ligand (RANKL)....

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Udgivet i:BMB Rep
Main Authors: Bak, Sun-Uk, Kim, Suji, Hwang, Hae-Jun, Yun, Jung-A, Kim, Wan-Sung, Won, Moo-Ho, Kim, Ji-Yoon, Ha, Kwon-Soo, Kwon, Young-Guen, Kim, Young-Myeong
Format: Artigo
Sprog:Inglês
Udgivet: Korean Society for Biochemistry and Molecular Biology 2017
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342874/
https://ncbi.nlm.nih.gov/pubmed/28088947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2017.50.2.220
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