Nutlin-3 inhibits androgen receptor-driven c-FLIP expression, resulting in apoptosis of prostate cancer cells

Inhibition of androgen receptor (AR) signalling represents the conventional medical management of prostate cancer. Ultimately this treatment fails because tumors develop an incurable, castrate resistant phenotype, resulting in an unmet need for new treatments in prostate cancer. The AR remains a via...

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Vydáno v:Oncotarget
Hlavní autoři: Logan, Ian R., McClurg, Urszula L., Jones, Dominic L., O'Neill, Daniel J., Shaheen, Fadhel S., Lunec, John, Gaughan, Luke, Robson, Craig N.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342697/
https://ncbi.nlm.nih.gov/pubmed/27729622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12542
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