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Temozolomide toxicity operates in a xCT/SLC7a11 dependent manner and is fostered by ferroptosis
The glutamate exchanger xCT (SLC7a11) is causally linked with the malignancy grade of brain tumors and represents a key player in glutamate, cystine and glutathione metabolism. Although blocking xCT is not cytotoxic for brain tumors, xCT inhibition disrupts the neurodegenerative and microenvironment...
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| Vydáno v: | Oncotarget |
|---|---|
| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Impact Journals LLC
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5342691/ https://ncbi.nlm.nih.gov/pubmed/27612422 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11858 |
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