IL-3 and CTLA4 gene polymorphisms may influence the tacrolimus dose requirement in Chinese kidney transplant recipients

The highly variable pharmacokinetics and narrow therapeutic window of tacrolimus (TAC) has hampered its clinical use. Genetic polymorphisms may contribute to the variable response, but the evidence is not compelling, and the explanation is unclear. In this study we attempted to find previously unkno...

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Vydáno v:Acta Pharmacol Sin
Hlavní autoři: Liu, Mou-ze, He, Hai-yan, Zhang, Yue-li, Hu, Yong-fang, He, Fa-zhong, Luo, Jian-quan, Luo, Zhi-ying, Chen, Xiao-ping, Liu, Zhao-qian, Zhou, Hong-hao, Shao, Ming-jie, Ming, Ying-zi, Xin, Hua-wen, Zhang, Wei
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342670/
https://ncbi.nlm.nih.gov/pubmed/28112181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2016.153
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