IL-3 and CTLA4 gene polymorphisms may influence the tacrolimus dose requirement in Chinese kidney transplant recipients

The highly variable pharmacokinetics and narrow therapeutic window of tacrolimus (TAC) has hampered its clinical use. Genetic polymorphisms may contribute to the variable response, but the evidence is not compelling, and the explanation is unclear. In this study we attempted to find previously unkno...

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Опубликовано в: :Acta Pharmacol Sin
Главные авторы: Liu, Mou-ze, He, Hai-yan, Zhang, Yue-li, Hu, Yong-fang, He, Fa-zhong, Luo, Jian-quan, Luo, Zhi-ying, Chen, Xiao-ping, Liu, Zhao-qian, Zhou, Hong-hao, Shao, Ming-jie, Ming, Ying-zi, Xin, Hua-wen, Zhang, Wei
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2017
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342670/
https://ncbi.nlm.nih.gov/pubmed/28112181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2016.153
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