Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis

Sepsis is a deleterious inflammatory response to infection with high mortality. Reliable sepsis biomarkers could improve diagnosis, prognosis, and treatment. Integration of human genetics, patient metabolite and cytokine measurements, and testing in a mouse model demonstrate that the methionine salv...

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Veröffentlicht in:Sci Adv
Hauptverfasser: Wang, Liuyang, Ko, Emily R., Gilchrist, James J., Pittman, Kelly J., Rautanen, Anna, Pirinen, Matti, Thompson, J. Will, Dubois, Laura G., Langley, Raymond J., Jaslow, Sarah L., Salinas, Raul E., Rouse, D. Clayburn, Moseley, M. Arthur, Mwarumba, Salim, Njuguna, Patricia, Mturi, Neema, Williams, Thomas N., Scott, J. Anthony G., Hill, Adrian V. S., Woods, Christopher W., Ginsburg, Geoffrey S., Tsalik, Ephraim L., Ko, Dennis C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2017
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342653/
https://ncbi.nlm.nih.gov/pubmed/28345042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1602096
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