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CpG-induced antitumor immunity requires IL-12 in expansion of effector cells and down-regulation of PD-1
CpG oligodeoxynucleotides, as a ligand of toll-like receptor (TLR)-9, have demonstrated promising antitumor effects in some clinical trials; however, its toxicity and low efficacy as a systemic therapy has limited its therapeutic applications. In order to improve its therapeutic efficacy, we investi...
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| Publicado no: | Oncotarget |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5342548/ https://ncbi.nlm.nih.gov/pubmed/27602959 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11833 |
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