Preclinical investigation of ibrutinib, a Bruton's kinase tyrosine (Btk) inhibitor, in suppressing glioma tumorigenesis and stem cell phenotypes

Standard interventions for glioma include surgery, radiation and chemotherapies but the prognosis for malignant cases such as glioblastoma multiforme remain grim. Even with targeted therapeutic agent, bevacitumab, malignant glioma often develops resistance and recurrence. Thus, developing alternativ...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wei, Li, Su, Yu-Kai, Lin, Chien-Min, Chao, Tsu-Yi, Huang, Shang-Pen, Huynh, Thanh-Tuan, Jan, Hsun-Jin, Whang-Peng, Jacqueline, Chiou, Jeng-Fong, Wu, Alexander T.H., Hsiao, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342527/
https://ncbi.nlm.nih.gov/pubmed/27564106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11572
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