Constitutive gp130 activation rapidly accelerates the transformation of human hepatocytes via an impaired oxidative stress response

Pro-inflammatory signaling pathways, especially interleukin 6 (IL-6), and reactive oxygen species (ROS) promote carcinogenesis in the liver. In order to elucidate the underlying oncogenic mechanism, we activated the IL-6 signal transducer glycoprotein 130 (gp130) via stable expression of a constitut...

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發表在:Oncotarget
Main Authors: Heim, Denise, Gil-Ibanez, Ines, Herden, Johannes, Parplys, Ann Christin, Borgmann, Kerstin, Schmidt-Arras, Dirk, Lohse, Ansgar W., Rose-John, Stefan, Wege, Henning
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2016
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Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342442/
https://ncbi.nlm.nih.gov/pubmed/27489351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10956
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