Acetylation of androgen receptor by ARD1 promotes dissociation from HSP90 complex and prostate tumorigenesis

Prostate cancer is an androgen receptor (AR)-driven disease and post-translational modification of AR is critical for AR activation. We previously reported that Arrest-defective protein 1 (ARD1) is an oncoprotein in prostate cancer. It acetylates and activates AR to promote prostate tumorigenesis. H...

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Vydáno v:Oncotarget
Hlavní autoři: DePaolo, John S., Wang, Zehua, Guo, Jianhui, Zhang, Guanyi, Qian, Chiping, Zhang, Haitao, Zabaleta, Jovanny, Liu, Wanguo
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342088/
https://ncbi.nlm.nih.gov/pubmed/27659526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12163
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