Dormant tumor cells expressing LOXL2 acquire a stem-like phenotype mediating their transition to proliferative growth

Recurrence of breast cancer disease years after treatment appears to arise from disseminated dormant tumor cells (DTC). The mechanisms underlying the outgrowth of DTC remain largely unknown. Here we demonstrate that dormant MCF-7 cells expressing LOXL2 acquire a cancer stem cell (CSC)-like phenotype...

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Vydáno v:Oncotarget
Hlavní autoři: Weidenfeld, Keren, Schif-Zuck, Sagi, Abu-Tayeh, Hanan, Kang, Keunsoo, Kessler, Ofra, Weissmann, Marina, Neufeld, Gera, Barkan, Dalit
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342084/
https://ncbi.nlm.nih.gov/pubmed/27655685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12109
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