Dormant tumor cells expressing LOXL2 acquire a stem-like phenotype mediating their transition to proliferative growth

Recurrence of breast cancer disease years after treatment appears to arise from disseminated dormant tumor cells (DTC). The mechanisms underlying the outgrowth of DTC remain largely unknown. Here we demonstrate that dormant MCF-7 cells expressing LOXL2 acquire a cancer stem cell (CSC)-like phenotype...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Weidenfeld, Keren, Schif-Zuck, Sagi, Abu-Tayeh, Hanan, Kang, Keunsoo, Kessler, Ofra, Weissmann, Marina, Neufeld, Gera, Barkan, Dalit
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342084/
https://ncbi.nlm.nih.gov/pubmed/27655685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12109
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