Dormant tumor cells expressing LOXL2 acquire a stem-like phenotype mediating their transition to proliferative growth

Recurrence of breast cancer disease years after treatment appears to arise from disseminated dormant tumor cells (DTC). The mechanisms underlying the outgrowth of DTC remain largely unknown. Here we demonstrate that dormant MCF-7 cells expressing LOXL2 acquire a cancer stem cell (CSC)-like phenotype...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Weidenfeld, Keren, Schif-Zuck, Sagi, Abu-Tayeh, Hanan, Kang, Keunsoo, Kessler, Ofra, Weissmann, Marina, Neufeld, Gera, Barkan, Dalit
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342084/
https://ncbi.nlm.nih.gov/pubmed/27655685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12109
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