Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis

Colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer-related mortality. Observed during CRC tumorigenesis is loss of post-transcriptional regulation of tumor-promoting genes such as COX-2, TNFα and VEGF. Overexpression of the RNA-binding protein HuR (ELAVL1) occurs d...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Blanco, Fernando F., Preet, Ranjan, Aguado, Andrea, Vishwakarma, Vikalp, Stevens, Laura E., Vyas, Alok, Padhye, Subhash, Xu, Liang, Weir, Scott J., Anant, Shrikant, Meisner-Kober, Nicole, Brody, Jonathan R., Dixon, Dan A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342034/
https://ncbi.nlm.nih.gov/pubmed/27677075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12189
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