Tetraspecific scFv construct provides NK cell mediated ADCC and self-sustaining stimuli via insertion of IL-15 as a cross-linker

BACKGROUND: The design of a highly effective anti-cancer immune-engager would include targeting of highly drug refractory cancer stem cells (CSC). The design would promote effective antibody-dependent cell-mediated cytotoxicity (ADCC) and simultaneously promote costimulation to expand and self-susta...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Schmohl, Joerg U., Felices, Martin, Todhunter, Deborah, Taras, Elizabeth, Miller, Jeffrey S., Vallera, Daniel A.
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2016
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342017/
https://ncbi.nlm.nih.gov/pubmed/27650544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12073
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