Antitumor activity of a novel anti-vascular endothelial growth factor receptor-1 monoclonal antibody that does not interfere with ligand binding

Vascular endothelial growth factor receptor-1 (VEGFR-1) is a tyrosine kinase transmembrane receptor that has also a soluble isoform containing most of the extracellular ligand binding domain (sVEGFR-1). VEGF-A binds to both VEGFR-2 and VEGFR-1, whereas placenta growth factor (PlGF) interacts exclusi...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Graziani, Grazia, Ruffini, Federica, Tentori, Lucio, Scimeca, Manuel, Dorio, Annalisa S., Atzori, Maria Grazia, Failla, Cristina M., Morea, Veronica, Bonanno, Elena, D'Atri, Stefania, Lacal, Pedro M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341950/
https://ncbi.nlm.nih.gov/pubmed/27655684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12108
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