TLR2 ligand-synthetic long peptide conjugates effectively stimulate tumor-draining lymph node T cells of cervical cancer patients

The potency of human papillomavirus type 16 (HPV16)-encoded synthetic long peptides (SLP), conjugated to an optimized Toll-like receptor 2 ligand (TLR2-L), was assessed in ex vivo activation of HPV16(+) cancer patient-derived T cells. Two highly immunogenic SLP sequences derived from the oncogenic E...

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Publicado en:Oncotarget
Autores principales: Zom, Gijs G., Welters, Marij J.P., Loof, Nikki M., Goedemans, Renske, Lougheed, Sinéad, Valentijn, Rob R.P.M., Zandvliet, Maarten L., Meeuwenoord, Nico J., Melief, Cornelis J.M., de Gruijl, Tanja D., Van der Marel, Gijsbert A., Filippov, Dmitri V., Ossendorp, Ferry, Van der Burg, Sjoerd H.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341859/
https://ncbi.nlm.nih.gov/pubmed/27564262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11512
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