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Structure-Activity Relationship in TLR4 Mutations: Atomistic Molecular Dynamics Simulations and Residue Interaction Network Analysis

Toll-like receptor 4 (TLR4), a vital innate immune receptor present on cell surfaces, initiates a signaling cascade during danger and bacterial intrusion. TLR4 needs to form a stable hexamer complex, which is necessary to dimerize the cytoplasmic domain. However, D299G and T399I polymorphism may abr...

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Publicat a:Sci Rep
Autors principals: Anwar, Muhammad Ayaz, Choi, Sangdun
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341570/
https://ncbi.nlm.nih.gov/pubmed/28272553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43807
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