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Integrating the GPCR transactivation‐dependent and biased signalling paradigms in the context of PAR1 signalling

Classically, receptor‐mediated signalling was conceived as a linear process involving one agonist, a variety of potential targets within a receptor family (e.g. α‐ and β‐adrenoceptors) and a second messenger (e.g. cAMP)‐triggered response. If distinct responses were stimulated by the same receptor i...

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Detalles Bibliográficos
Publicado en:Br J Pharmacol
Autores principales: Little, PJ, Hollenberg, MD, Kamato, D, Thomas, W, Chen, J, Wang, T, Zheng, W, Osman, N
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341248/
https://ncbi.nlm.nih.gov/pubmed/26624252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13398
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