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Integrating the GPCR transactivation‐dependent and biased signalling paradigms in the context of PAR1 signalling
Classically, receptor‐mediated signalling was conceived as a linear process involving one agonist, a variety of potential targets within a receptor family (e.g. α‐ and β‐adrenoceptors) and a second messenger (e.g. cAMP)‐triggered response. If distinct responses were stimulated by the same receptor i...
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| Опубликовано в: : | Br J Pharmacol |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
John Wiley and Sons Inc.
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5341248/ https://ncbi.nlm.nih.gov/pubmed/26624252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13398 |
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