Mechanisms by which the thiazolidinedione troglitazone protects against sucrose‐induced hepatic fat accumulation and hyperinsulinaemia

BACKGROUND AND PURPOSE: Thiazolidinediones (TZD) are known to ameliorate fatty liver in type 2 diabetes. To date, the underlying mechanisms of their hepatic actions remain unclear. EXPERIMENTAL APPROACH: Hepatic triglyceride content and export rates were assessed in 2 week high‐sucrose‐fed Wistar ra...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Martins, Fátima O, Delgado, Teresa C, Viegas, Joana, Gaspar, Joana M, Scott, Donald K, O'Doherty, Robert M, Paula Macedo, M, Jones, John G
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341231/
https://ncbi.nlm.nih.gov/pubmed/26447327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13362
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