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Copper carbenes alkylate guanine chemoselectively through a substrate directed reaction
Cu(i) carbenes derived from α-diazocarbonyl compounds lead to selective alkylation of the O(6) position in guanine (O(6)-G) in mono- and oligonucleotides. Only purine-type lactam oxygens are targeted – other types of amides or lactams are poorly reactive under conditions that give smooth alkylation...
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| Pubblicato in: | Chem Sci |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Royal Society of Chemistry
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5341205/ https://ncbi.nlm.nih.gov/pubmed/28451197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc03502g |
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