Novel determinants of mammalian primary microRNA processing revealed by systematic evaluation of hairpin-containing transcripts and human genetic variation

Mature microRNAs (miRNAs) are processed from hairpin-containing primary miRNAs (pri-miRNAs). However, rules that distinguish pri-miRNAs from other hairpin-containing transcripts in the genome are incompletely understood. By developing a computational pipeline to systematically evaluate 30 structural...

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Dettagli Bibliografici
Pubblicato in:Genome Res
Autori principali: Roden, Christine, Gaillard, Jonathan, Kanoria, Shaveta, Rennie, William, Barish, Syndi, Cheng, Jijun, Pan, Wen, Liu, Jun, Cotsapas, Chris, Ding, Ye, Lu, Jun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2017
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340965/
https://ncbi.nlm.nih.gov/pubmed/28087842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.208900.116
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