Novel determinants of mammalian primary microRNA processing revealed by systematic evaluation of hairpin-containing transcripts and human genetic variation

Mature microRNAs (miRNAs) are processed from hairpin-containing primary miRNAs (pri-miRNAs). However, rules that distinguish pri-miRNAs from other hairpin-containing transcripts in the genome are incompletely understood. By developing a computational pipeline to systematically evaluate 30 structural...

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Vydáno v:Genome Res
Hlavní autoři: Roden, Christine, Gaillard, Jonathan, Kanoria, Shaveta, Rennie, William, Barish, Syndi, Cheng, Jijun, Pan, Wen, Liu, Jun, Cotsapas, Chris, Ding, Ye, Lu, Jun
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2017
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340965/
https://ncbi.nlm.nih.gov/pubmed/28087842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.208900.116
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