New approaches for the reliable in vitro assessment of binding affinity based on high-resolution real-time data acquisition of radioligand-receptor binding kinetics

BACKGROUND: Resolving the kinetic mechanisms of biomolecular interactions have become increasingly important in early-phase drug development. Since traditional in vitro methods belong to dose-dependent assessments, binding kinetics is usually overlooked. The present study aimed at the establishment...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:EJNMMI Res
Auteurs principaux: Zeilinger, Markus, Pichler, Florian, Nics, Lukas, Wadsak, Wolfgang, Spreitzer, Helmut, Hacker, Marcus, Mitterhauser, Markus
Format: Artigo
Langue:Inglês
Publié: Springer Berlin Heidelberg 2017
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340791/
https://ncbi.nlm.nih.gov/pubmed/28271461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-016-0249-9
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires