New approaches for the reliable in vitro assessment of binding affinity based on high-resolution real-time data acquisition of radioligand-receptor binding kinetics

BACKGROUND: Resolving the kinetic mechanisms of biomolecular interactions have become increasingly important in early-phase drug development. Since traditional in vitro methods belong to dose-dependent assessments, binding kinetics is usually overlooked. The present study aimed at the establishment...

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Detalhes bibliográficos
Publicado no:EJNMMI Res
Main Authors: Zeilinger, Markus, Pichler, Florian, Nics, Lukas, Wadsak, Wolfgang, Spreitzer, Helmut, Hacker, Marcus, Mitterhauser, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340791/
https://ncbi.nlm.nih.gov/pubmed/28271461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-016-0249-9
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