Chemical Enhancement of In Vitro and In Vivo Direct Cardiac Reprogramming

BACKGROUND: Reprogramming of cardiac fibroblasts into induced cardiomyocyte-like cells (iCMs) in situ represents a promising strategy for cardiac regeneration. A combination of three cardiac transcription factors, Gata4, Mef2c and Tbx5 (GMT), can convert fibroblasts into iCMs, albeit with low effici...

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Veröffentlicht in:Circulation
Hauptverfasser: Mohamed, Tamer M. A., Stone, Nicole R., Berry, Emily C., Radzinsky, Ethan, Huang, Yu, Pratt, Karishma, Ang, Yen-Sin, Yu, Pengzhi, Wang, Haixia, Tang, Shibing, Magnitsky, Sergey, Ding, Sheng, Ivey, Kathryn N., Srivastava, Deepak
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340593/
https://ncbi.nlm.nih.gov/pubmed/27834668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.116.024692
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