Context-Specific Transcription Factor Functions Regulate Epigenomic and Transcriptional Dynamics During Cardiac Reprogramming

Ectopic expression of combinations of transcription factors (TF) can drive direct lineage conversion, thereby reprogramming a somatic cell’s identity. To determine the molecular mechanisms by which Gata4, Mef2c, and Tbx5 (GMT) induce conversion from a cardiac fibroblast toward an induced cardiomyocy...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Stem Cell
Prif Awduron: Stone, Nicole R., Gifford, Casey A., Thomas, Reuben, Pratt, Karishma J. B., Samse-Knapp, Kaitlen, Mohamed, Tamer M. A., Radzinsky, Ethan M., Schricker, Amelia, Ye, Lin, Yu, Pengzhi, van Bemmel, Joke G., Ivey, Kathryn N., Pollard, Katherine S., Srivastava, Deepak
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6632093/
https://ncbi.nlm.nih.gov/pubmed/31271750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.06.012
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