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DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway
Stabilization of mutant p53 (mutp53) in tumours greatly contributes to malignant progression. However, little is known about the underlying mechanisms and therapeutic approaches to destabilize mutp53. Here, through high-throughput screening we identify statins, cholesterol-lowering drugs, as degrada...
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| Izdano u: | Nat Cell Biol |
|---|---|
| Glavni autori: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5340314/ https://ncbi.nlm.nih.gov/pubmed/27775703 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3427 |
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