Indoleamine 2,3-dioxygenase regulates anti-tumor immunity in lung cancer by metabolic reprogramming of immune cells in the tumor microenvironment

Indoleamine 2,3-dioxygenase (IDO) has been implicated in immune evasion by tumors. Upregulation of this tryptophan (Trp)-catabolizing enzyme, in tumor cells and myeloid-derived suppressor cells (MDSCs) within the tumor microenvironment (TME), leads to Trp depletion that impairs cytotoxic T cell resp...

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Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Schafer, Cara C., Wang, Yong, Hough, Kenneth P., Sawant, Anandi, Grant, Stefan C., Thannickal, Victor J., Zmijewski, Jaroslaw, Ponnazhagan, Selvarangan, Deshane, Jessy S.
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2016
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340181/
https://ncbi.nlm.nih.gov/pubmed/27705910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12249
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