Loss of UHRF2 expression is associated with human neoplasia, promoter hypermethylation, decreased 5-hydroxymethylcytosine, and high proliferative activity

Ubiquitin-like with PHD and ring finger domains 2 (UHRF2) binds to 5-hydroxymethylcytosine (5hmC), a DNA base involved in tissue development, but it is unknown how their distribution compares with each other in normal and malignant human tissues. We used IHC on human tumor specimens (160 from 19 tum...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Lu, Huarui, Bhoopatiraju, Sweta, Wang, Hongbo, Schmitz, Nolan P., Wang, Xiaohong, Freeman, Matthew J., Forster, Colleen L., Verneris, Michael R., Linden, Michael A., Hallstrom, Timothy C.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340178/
https://ncbi.nlm.nih.gov/pubmed/27738314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12583
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