Inhibition of SRF/myocardin reduces aortic stiffness by targeting vascular smooth muscle cell stiffening in hypertension

AIMS: Increased aortic stiffness is a fundamental manifestation of hypertension. However, the molecular mechanisms involved remain largely unknown. We tested the hypothesis that abnormal intrinsic vascular smooth muscle cell (VSMC) mechanical properties in large arteries, but not in distal arteries,...

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Detaylı Bibliyografya
Yayımlandı:Cardiovasc Res
Asıl Yazarlar: Zhou, Ning, Lee, Jia-Jye, Stoll, Shaunrick, Ma, Ben, Wiener, Robert, Wang, Charles, Costa, Kevin D., Qiu, Hongyu
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2017
Konular:
Original Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340142/
https://ncbi.nlm.nih.gov/pubmed/28003268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvw222
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