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Noncanonical SQSTM1/p62-Nrf2 pathway activation mediates proteasome inhibitor resistance in multiple myeloma cells via redox, metabolic and translational reprogramming

Multiple Myeloma (MM) is a B-cell malignancy characterized by the accumulation of clonal plasma cells in the bone marrow, with drug resistance being a major cause of therapeutic failure. We established a carfilzomib-resistant derivative of the LP-1 MM cell line (LP-1/Cfz) and found that the transcri...

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Vydáno v:Oncotarget
Hlavní autoři: Riz, Irene, Hawley, Teresa S., Marsal, Jeffrey W., Hawley, Robert G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340085/
https://ncbi.nlm.nih.gov/pubmed/27626179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11960
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