Improved Bioavailability and Antitumor Effect of Docetaxel by TPGS Modified Proniosomes: In Vitro and In Vivo Evaluations

A novel oral drug delivery system, TPGS modified docetaxel proniosomes (DTX-TPGS-PNs), was designed to enhance the oral bioavailability and antitumor efficiency of the poorly water-soluble drug docetaxel. DTX-TPGS-PN niosomes were 93 ± 6.5 nm in size, −18.53 ± 1.65 mV in zeta potential and exhibited...

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發表在:Sci Rep
Main Authors: Liu, Helong, Tu, Liangxing, Zhou, Yongxin, Dang, Zefang, Wang, Luting, Du, Junfeng, Feng, Jianfang, Hu, Kaili
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339906/
https://ncbi.nlm.nih.gov/pubmed/28266539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43372
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