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Selective induction of alternatively spliced FynT isoform by TNF facilitates persistent inflammatory responses in astrocytes

Fyn tyrosine kinase has been implicated in the pathogenesis of Alzheimer’s disease (AD). We have previously reported that upregulation of the FynT isoform in AD brains was partly associated with astrocyte activation. In this study, we demonstrated selective FynT induction in murine cortex and primar...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Lee, Chingli, Low, Clara Y. B., Wong, Siew Ying, Lai, Mitchell K. P., Tan, Michelle G. K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2017
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339870/
https://ncbi.nlm.nih.gov/pubmed/28266558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43651
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