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Selective induction of alternatively spliced FynT isoform by TNF facilitates persistent inflammatory responses in astrocytes

Fyn tyrosine kinase has been implicated in the pathogenesis of Alzheimer’s disease (AD). We have previously reported that upregulation of the FynT isoform in AD brains was partly associated with astrocyte activation. In this study, we demonstrated selective FynT induction in murine cortex and primar...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lee, Chingli, Low, Clara Y. B., Wong, Siew Ying, Lai, Mitchell K. P., Tan, Michelle G. K.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339870/
https://ncbi.nlm.nih.gov/pubmed/28266558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43651
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