Specific Inhibition of Acyl-CoA Oxidase-1 by an Acetylenic Acid Improves Hepatic Lipid and Reactive Oxygen Species (ROS) Metabolism in Rats Fed a High Fat Diet

A chronic high fat diet results in hepatic mitochondrial dysfunction and induction of peroxisomal fatty acid oxidation (FAO); whether specific inhibition of peroxisomal FAO benefits mitochondrial FAO and reactive oxygen species (ROS) metabolism remains unclear. In this study a specific inhibitor for...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Zeng, Jia, Deng, Senwen, Wang, Yiping, Li, Ping, Tang, Lian, Pang, Yefeng
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339762/
https://ncbi.nlm.nih.gov/pubmed/28077576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.763532
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