A Quininib Analogue and Cysteinyl Leukotriene Receptor Antagonist Inhibits Vascular Endothelial Growth Factor (VEGF)-independent Angiogenesis and Exerts an Additive Antiangiogenic Response with Bevacizumab

Excess blood vessel growth contributes to the pathology of metastatic cancers and age-related retinopathies. Despite development of improved treatments, these conditions are associated with high economic costs and drug resistance. Bevacizumab (Avastin®), a monoclonal antibody against vascular endoth...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Butler, Clare T., Reynolds, Alison L., Tosetto, Miriam, Dillon, Eugene T., Guiry, Patrick J., Cagney, Gerard, O'Sullivan, Jacintha, Kennedy, Breandán N.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2017
Sujets:
Molecular Bases of Disease
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339742/
https://ncbi.nlm.nih.gov/pubmed/28035003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.747766
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