Functional Genetic Screen for Genes Involved in Senescence: Role of Tid1, a Homologue of the Drosophila Tumor Suppressor l(2)tid, in Senescence and Cell Survival

We performed a genetic suppressor element screen to identify genes whose inhibition bypasses cellular senescence. A normalized library of fragmented cDNAs was used to select for elements that promote immortalization of rat embryo fibroblasts. Fragments isolated by the screen include those with homol...

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Detalhes bibliográficos
Main Authors: Tarunina, Marina, Alger, Lynsey, Chu, Grace, Munger, Karl, Gudkov, Andrei, Jat, Parmjit S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC533960/
https://ncbi.nlm.nih.gov/pubmed/15572682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.24.10792-10801.2004
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