Inhibition of Parainfluenza Virus Type 3 and Newcastle Disease Virus Hemagglutinin-Neuraminidase Receptor Binding: Effect of Receptor Avidity and Steric Hindrance at the Inhibitor Binding Sites

Zanamivir (4-guanidino-Neu5Ac2en [4-GU-DANA]) inhibits not only the neuraminidase activity but also the receptor interaction of the human parainfluenza virus type 3 (HPIV3) hemagglutinin-neuraminidase (HN), blocking receptor binding and subsequent fusion promotion. All activities of the HPIV3 varian...

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Detalhes bibliográficos
Main Authors: Porotto, Matteo, Murrell, Matthew, Greengard, Olga, Lawrence, Michael C., McKimm-Breschkin, Jennifer L., Moscona, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC533954/
https://ncbi.nlm.nih.gov/pubmed/15564499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.24.13911-13919.2004
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