A Single Amino Acid Alteration in the Human Parainfluenza Virus Type 3 Hemagglutinin-Neuraminidase Glycoprotein Confers Resistance to the Inhibitory Effects of Zanamivir on Receptor Binding and Neuraminidase Activity

Entry and fusion of human parainfluenza virus type 3 (HPF3) requires interaction of the viral hemagglutinin-neuraminidase (HN) glycoprotein with its sialic acid receptor. 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid (4-GU-DANA; zanamivir), a sialic acid transition-state analog designe...

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Detalhes bibliográficos
Main Authors: Murrell, Matthew T., Porotto, Matteo, Greengard, Olga, Poltoratskaia, Natalia, Moscona, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114353/
https://ncbi.nlm.nih.gov/pubmed/11413297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.14.6310-6320.2001
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