Identification of Severe Acute Respiratory Syndrome Coronavirus Replicase Products and Characterization of Papain-Like Protease Activity

Gene 1 of the coronavirus associated with severe acute respiratory syndrome (SARS) encodes replicase polyproteins that are predicted to be processed into 16 nonstructural proteins (nsps 1 to 16) by two viral proteases, a papain-like protease (PLpro) and a 3C-like protease (3CLpro). Here, we identify...

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Main Authors: Harcourt, Brian H., Jukneliene, Dalia, Kanjanahaluethai, Amornrat, Bechill, John, Severson, Kari M., Smith, Catherine M., Rota, Paul A., Baker, Susan C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2004
Fag:
Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC533933/
https://ncbi.nlm.nih.gov/pubmed/15564471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.24.13600-13612.2004
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