Two Amino Acid Mutations in the Capsid Protein of Type 2 Porcine Circovirus (PCV2) Enhanced PCV2 Replication In Vitro and Attenuated the Virus In Vivo

Porcine circovirus type 2 (PCV2) is the primary causative agent of postweaning multisystemic wasting syndrome (PMWS) in pigs. To identify potential genetic determinants for virulence and replication, we serially passaged a PCV2 isolate 120 times in PK-15 cells. The viruses harvested at virus passage...

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Detalhes bibliográficos
Main Authors: Fenaux, M., Opriessnig, T., Halbur, P. G., Elvinger, F., Meng, X. J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC533909/
https://ncbi.nlm.nih.gov/pubmed/15564454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.24.13440-13446.2004
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