Loss of hypothalamic corticotropin-releasing hormone markedly reduces anxiety behaviors in mice

A long-standing paradigm posits that hypothalamic corticotropin-releasing hormone (CRH) regulates neuroendocrine functions such as adrenal glucocorticoid release, while extra-hypothalamic CRH plays a key role in stressor-triggered behaviors. Here we report that hypothalamus-specific Crh knockout mic...

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Detalhes bibliográficos
Publicado no:Mol Psychiatry
Main Authors: Zhang, Rong, Asai, Masato, Mahoney, Carrie E, Joachim, Maria, Shen, Yuan, Gunner, Georgia, Majzoub, Joseph A
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339066/
https://ncbi.nlm.nih.gov/pubmed/27595593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2016.136
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