In silico discovery and in vitro activity of inhibitors against Mycobacterium tuberculosis 7,8-diaminopelargonic acid synthase (Mtb BioA)

Computer-aided drug discovery and development approaches such as virtual screening, molecular docking, and in silico drug property calculations have been utilized in this effort to discover new lead compounds against tuberculosis. The enzyme 7,8-diaminopelargonic acid aminotransferase (BioA) in Myco...

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Détails bibliographiques
Publié dans:Drug Des Devel Ther
Auteurs principaux: Billones, Junie B, Carrillo, Maria Constancia O, Organo, Voltaire G, Sy, Jamie Bernadette A, Clavio, Nina Abigail B, Macalino, Stephani Joy Y, Emnacen, Inno A, Lee, Alexandra P, Ko, Paul Kenny L, Concepcion, Gisela P
Format: Artigo
Langue:Inglês
Publié: Dove Medical Press 2017
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338852/
https://ncbi.nlm.nih.gov/pubmed/28280303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S119930
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