Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice

We previously reported a genetic analysis of heart failure traits in a population of inbred mouse strains treated with isoproterenol to mimic catecholamine-driven cardiac hypertrophy. Here, we apply a co-expression network algorithm, wMICA, to perform a systems-level analysis of left ventricular tra...

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Pubblicato in:Cell Syst
Autori principali: Rau, Christoph D., Romay, Milagros C., Tuteryan, Mary, Wang, Jessica J.-C., Santolini, Marc, Ren, Shuxun, Karma, Alain, Weiss, James N., Wang, Yibin, Lusis, Aldons J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338604/
https://ncbi.nlm.nih.gov/pubmed/27866946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2016.10.016
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