Improved regulatory element prediction based on tissue-specific local epigenomic signatures

Accurate enhancer identification is critical for understanding the spatiotemporal transcriptional regulation during development as well as the functional impact of disease-related noncoding genetic variants. Computational methods have been developed to predict the genomic locations of active enhance...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: He, Yupeng, Gorkin, David U., Dickel, Diane E., Nery, Joseph R., Castanon, Rosa G., Lee, Ah Young, Shen, Yin, Visel, Axel, Pennacchio, Len A., Ren, Bing, Ecker, Joseph R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338528/
https://ncbi.nlm.nih.gov/pubmed/28193886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1618353114
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