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Phosphorylation of αB-crystallin supports reactive astrogliosis in demyelination

The small heat shock protein αB-crystallin (CRYAB) has been implicated in multiple sclerosis (MS) pathogenesis. Earlier studies have indicated that CRYAB inhibits inflammation and attenuates clinical disease when administered in the experimental autoimmune encephalomyelitis model of MS. In this stud...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Kuipers, Hedwich F., Yoon, Jane, van Horssen, Jack, Han, May H., Bollyky, Paul L., Palmer, Theo D., Steinman, Lawrence
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338510/
https://ncbi.nlm.nih.gov/pubmed/28196893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1621314114
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